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Wondershare EdrawMax v12.0.1.923 Ultimate Pre-Activated Īll-in-One Diagram Software. 32bit | 64bit | Silent Install | PreActivated The owner of Chop Shop uses WhatsApp Business App and he gets additional benefits.Her personal and business communication is all mixed up and there are no business features in the app to help her out, so sometimes clients have to wait for a long time before they get an answer. The owner of Curl Me Crazy uses her personal WhatsApp account to communicate with customers, it helps her engage with clients but it has some drawbacks.Curl Me Crazy and Chop Shop are small local businesses while A Little Off The Top is a well established chain of hair salons. In New York there are 3 hair salons which all use WhatsApp to communicate with customers. They were launched in 2018 and are already used by more than 3 million businesses.Ī simple story will help us get a general idea of the different audiences the 3 WhatsApp products are designed for. 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This review focuses on mechanistic aspects of HR relating to DSB and ICL repair as well as replication fork support.ĭNA damage is a fact of life as a consequence of endogenous sources and processes as well as exogenous sources 1. The cellular functions of recombination are also germane to DNA-based treatment modalities of cancer, which target replicating cells by the direct or indirect induction of DNA lesions that are substrates for recombination pathways. Mutations in the BRCA2 recombination gene cause predisposition to breast and ovarian cancer as well as Fanconi anemia, a cancer predisposition syndrome characterized by a defect in the repair of DNA interstrand crosslinks. The inability to properly repair complex DNA damage and resolve DNA replication stress leads to genomic instability and contributes to cancer etiology. The diverse functions of recombination are reflected in the need for context-specific factors that perform supplemental functions in conjunction with the core proteins. A central core of proteins, most critically the RecA homolog Rad51, catalyzes the key reactions that typify HR: homology search and DNA strand invasion. In addition, recombination provides critical support for DNA replication in the recovery of stalled or broken replication forks, contributing to tolerance of DNA damage. Homologous recombination (HR) comprises a series of interrelated pathways that function in the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). |